Accupril |
Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting
enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension
and congestive heart failure. Pharmacology Quinapril is a prodrug. It is converted to its active metabolite, quinaprilat, in the liver. Mechanism of action Main article: ACE inhibitor See also: Angiotensin and renin-angiotensin system Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood. Indications Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure. Contraindications Pregnancy Impaired renal and liver function Patients with a history of angioedema related to previous treatment with an ACE inhibitor. Hypersensitive to Quinapril [edit] Side effects Side effects of quinapril include dizziness, cough, vomiting, upset stomach and fatigue. |